Natively unfolded proteins


 

We use molecular simulation methods to examine a variety of biological phenomena while pursuing questions that cannot be addressed by laboratory experiments.  Our research falls into three main areas:

1) Development of atomistic simulation approaches for sampling “rare”, but fast events such as protein folding, binding, and switching, with realistic kinetics on large-scale computing resources, including supercomputers and distributed computed networks.
2) Application of coarse-grained simulation approaches to aid the design of bi-functional, two-domain protein switches that function through “mutually exclusive folding”.
3) Application of implicit and explicit solvent models to examine the desolvation costs of salt bridges across protein binding interfaces.

 

 


Education

PhD 2002, University of California at San Francisco

Postdoctoral Training

Stanford University/IBM Almaden Research Center


Department of Chemistry
University of Pittsburgh
219 Parkman Avenue
Pittsburgh, PA 15260

Phone: (412) 624-6026
Fax: (412) 624-8301

E-mail: ltchong@pitt.edu

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