Our lab studies the nucleotide excision repair (NER) pathway in DNA repair. My thesis project is currently focused on mechanism of DNA damage recognition by yeast NER protein Rad4-Rad23, using single-molecule techniques such as our DNA tightrope assay with quantum dot labeled proteins, as well as atomic force microscopy (AFM).
B.A. Physics, Knox College 2008
M.S. Physics, CMU 2010
PhD Advisor: Dr. Bennet Van Houten
Hillman Cancer Center Research Pavilion Lab 2.1
5117 Centre Ave
Pittsburgh, PA 15232
- Van Houten, B., and Kong, M. (2015) Eukaryotic Nucleotide Excision Repair, in Encyclopedia of Cell Biology, edited by Ralph A. Bradshaw and Philip D. Stahl, Academic Press.
- Kong M, Liu L, Chen X, Drisöhmcoll KI, Mao P, B S, Kad NM, Watkins SC, Bernstein KA, Wyrick JJ, Min JH, Van Houten B. Single-Molecule Imaging Reveals that Rad4 Employs a Dynamic DNA Damage Recognition Process. Mol Cell. 2016 Oct 20;64(2):376-387
- Kong M, Van Houten B. Rad4 recognition-at-a-distance: Physical basis of conformation-specific anomalous diffusion of DNA repair proteins. Prog Biophys Mol Biol. 2016 Dec 7. pii: S0079-6107(16)30150-X
- Luo J, Kong M, Liu L, Samanta S, Van Houten B, Deiters A. Optical Control of DNA Helicase Function through Genetic Code Expansion. Chembiochem. 2017;18(5):466-469
- Kong M, Beckwitt EC, Springall L, Kad NM, Van Houten B. Single-Molecule Methods for Nucleotide Excision Repair: Building a System to Watch Repair in Real Time. Methods in Enzymology, DNA Repair Enzymes, Part B, Volume 592, Academic Press, 2017, in press