My current research seeks to gain structural information of the parathyroid hormone receptor (PTHR), a membrane protein critical to bone and kidney health. PTHR is a G protein-coupled receptor. Multiple endogenous ligands bind to PTHR, and each ligand has unique signaling properties. To understand the mechanisms of ligand binding and PTHR activation, I aim to solve high-resolution structures of PTHR and PTHR-containing complexes using X-ray crystallography and electron microscopy.
Biology BA, Truman State University, 2014
PhD Advisor: Dr. Guillermo Calero
1043 Biomedical Science Tower 3
3501 Fifth Ave. Pittsburgh, PA 15213
- Stevenson HP, Lin G, Barnes CO, Sutkeviciute I, Krzysiak T, Weiss SC, Reynolds S, Wu Y, Natarajan V, Makhov AM, Lawrence R, Lamm E, Clark L, Gardella TJ, Hogue BG, Ogata CM, Ahn J, Gronenborn AM, Conway JF, Vilardaga JP, Cohen AE, Calero G. (2016) Transmission electron microscopy for the evaluation and optimization of crystal growth. Acta Crystallogr D Struct Biol. 72(Pt 5):603-15