“Regulating CRISPR/Cas9 Function through Conditional Guide RNA Control”
Wes Brown, a student in the MBSB and member of the Deiters lab in the Department of Chemistry, has recently published a review on conditional control of CRISPR/Cas9 function through modification of the guide RNA (gRNA). They discuss control of gRNAs by light, small molecules, proteins, and oligonucleotides. These designs have unique advantages compared to other approaches and have allowed precise regulation of gene editing and transcription.
By the MBSB