20241106 

Tristin Schwartze, a student in the MBSB Program, successfully defended his thesis on November 6th to complete his Ph.D. The title of his presentation and thesis is “Molecular basis of interchain disulfide-bond formation in BMP-9 and BMP-10”. Tristin performed this research under the supervision of Prof. Andrew Hinck in the Department of Structural Biology at the University of Pittsburgh School of Medicine. Bone Morphogenetic Proteins, BMP9 and BMP10, are secreted proteins essential for regulating the proper development of vascular networks, thus understanding how they are synthesized and is important developing therapies for vascular diseases, such as Hereditary Hemorrhagic Telangiectasia (HHT), which are caused by mutations in the non-redundant receptors that mediate BMP9/10 signaling. Tristin mainly presented about the dimerization mechanisms of these proteins.

Congratulations, Tristin!

Please check the student and faculty websites;

https://www.hincklab.structbio.pitt.edu/

http://www.mbsb.pitt.edu/index.php/site-map/articles/85-students/274-tristin-schwartze

By MBSB