Study of synthetic protein analogues
Research in the Horne lab is focused on the design, synthesis and study of synthetic analogues of polypeptides and proteins. The cellular machinery underlying life is based on biopolymers (proteins and nucleic acids) comprised of a handful of simple building blocks. Application of the principles of synthetic organic chemistry to the modification of proteins provides an avenue to chemical species that are inspired by nature but manifest new and interesting properties. We are working to develop synthetically modified peptides and proteins as bio-inspired materials, scaffolds for the development of therapeutics that act by blocking protein-protein interactions involved in disease, and probes to study natural biological processes.
Education
PhD,Scripps Research Institute
Postdoctoral Training
University of Wisconsin - Madison
Department of Chemistry
University of Pittsburgh
219 Parkman Ave.
1405 Chevron Science Center
Pittsburgh, PA 15260
Phone: (412) 624-8700
Fax: (412) 624-8611
E-mail: horne@pitt.edu
