NMR & computations of protein structures, dynamics, & drug effects
Research in the Tang Group focuses on the structures and dynamics of membrane proteins, which are the primary targets for many classes of drugs. The current research efforts are directed at understanding where and how low-affinity drugs interact with proteins and what structural and dynamical consequences are on these proteins due to drug binding. Both experimental (primarily NMR) and computational (primarily MD simulations) approaches are taken in the investigations. The ultimate goal is to understand the molecular mechanisms of the action of low-affinity drugs and to devise rational designs of safer drugs with minimal side effects.
Department of Anesthesiology
Department of Pharmacology and Biological Chemistry
Department of Computational Biology
Education
PhD 1990, State University of New York at Stony Brook
Postdoctoral Training
1990-1993, University of California, Berkeley
Department of Pharmacology & Chemical Biology
University of Pittsburgh
Room 2049
Biomedical Science Tower 3
3501 Fifth Avenue
Pittsburgh, PA 15260
Phone: (412) 624-8783
Fax: (412) 648-8998
E-mail: tangp@anes.upmc.edu
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