Thesis Title: “Investigations of Structural and Dynamics of Transmembrane Proteins and Implications in the Action of Inhalational Anesthetics.”
Graduation Date: 2010
MBSB PhD Advisor: Prof. Yan Xu (Dept. of Anesthesiology, U of Pitt)
Current location: Senior Development Scientist at Scientific Protein Labs (Madison, WI).
Publications:
- Mowrey DD, Cui T, Jia Y, Ma D, Makhov AM, Zhang P, Tang P, Xu Y. Open-channel structures of the human glycine receptor α1 full-length transmembrane domain. Structure. 2013;21(10):1897-904
- Bondarenko V, Mowrey D, Tillman T, Cui T, Liu LT, Xu Y, Tang P. NMR structures of the transmembrane domains of the α4β2 nAChR. Biochim Biophys Acta. 2012 May;1818(5):1261-8.
- Cui T, Mowrey D, Bondarenko V, Tillman T, Ma D, Landrum E, Perez-Aguilar JM, He J, Wang W, Saven JG, Eckenhoff RG, Tang P, Xu Y. (2012) NMR structure and dynamics of a designed water-soluble transmembrane domain of nicotinic acetylcholine receptor. Biochim Biophys Acta. 2012 Mar;1818(3):617-26
- Xiong W, Cheng K, Cui T, Godlewski G, Rice KC, Xu Y, Zhang L. Cannabinoid potentiation of glycine receptors contributes to cannabis-induced analgesia. Nat Chem Biol. 2011 May;7(5):296-303
- Cui T, Canlas CG, Xu Y, Tang P. Anesthetic effects on the structure and dynamics of the second transmembrane domains of nAChR alpha4beta2. Biochim Biophys Acta. 2010 Feb;1798(2):161-6
- Canlas CG, Cui T, Li L, Xu Y, Tang P. Anesthetic modulation of protein dynamics: insight from an NMR study. J Phys Chem B. 2008 Nov 13;112(45):14312-8
- Ma D, Brandon NR, Cui T, Bondarenko V, Canlas C, Johansson JS, Tang P, Xu Y. Four-alpha-helix bundle with designed anesthetic binding pockets. Part I: structural and dynamical analyses. Biophys J. 2008 Jun;94(11):4454-63
- Cui T, Bondarenko V, Ma D, Canlas C, Brandon NR, Johansson JS, Xu Y, Tang P. Four-alpha-helix bundle with designed anesthetic binding pockets. Part II: halothane effects on structure and dynamics. Biophys J. 2008 Jun;94(11):4464-72
