Thesis Title: "The Kinetics and Thermodynamics of Polyglutamine Aggregation."
Graduation Date: 2013
MBSB PhD Advisor: Dr. Ronald Wetzel (Dept. Structural Biology, University of Pittsburgh School of Medicine)
Research interests:
Current location: Senior Scientific Specialist at Tunnel Government Services (Washington DC area)
Education:
B.A., Physics, Cornell University
Ph.D., Structural Biology & Molecular Biophysics, University of Pittsburgh, 2013
Publications:
- Mishra R, Jayaraman M, Roland BP, Landrum E, Fullam T, Kodali R, Thakur AK, Arduini I, Wetzel R. (2012) Inhibiting the nucleation of amyloid structure in a huntingtin fragment by targeting α-helix-rich oligomeric intermediates. J Mol Biol. 2012 Feb 3;415(5):900-17
- Cui T, Mowrey D, Bondarenko V, Tillman T, Ma D, Landrum E, Perez-Aguilar JM, He J, Wang W, Saven JG, Eckenhoff RG, Tang P, Xu Y. (2012) NMR structure and dynamics of a designed water-soluble transmembrane domain of nicotinic acetylcholine receptor. Biochim Biophys Acta. 1818(3):617-26
- Landrum E, Wetzel R. Biophysical underpinnings of the repeat length dependence of polyglutamine amyloid formation. J Biol Chem. 2014;289(15):10254-60
