Thesis title: "Conformational Dynamics of Proteins: Insights from Structural and Computational Studies"
Graduation Date: 2011
PhD Advisors: Angela Gronenborn and Ivet Bahar
Current location: postdoctoral research at UCSF, where she continues to combine experimental and computational approaches, in the Fraser and Kortemme labs.
Education:
B.S., Biological Science, University of Science and Technology of China (USTC), 2004
Ph.D., Molecular Biophysics and Structural Biology, University of Pittsburgh, 2011
Publications:
- Koharudin LM, Liu L, Gronenborn AM. Different 3D domain-swapped oligomeric cyanovirin-N structures suggest trapped folding intermediates. Proc Natl Acad Sci U S A. 2013; 110(19):7702-7
- Liu L, Byeon IJ, Bahar I, Gronenborn AM. Domain swapping proceeds via complete unfolding: a 19F- and 1H-NMR study of the Cyanovirin-N protein. J Am Chem Soc 2012;134(9):4229-35.
- Liu L, Gronenborn, AM, and Bahar, I. Longer simulations sample larger subspaces of conformations while maintaining robust mechanisms of motion. Proteins 2012, 80: 616–625.
- Liu L and Gronenborn AM. Domain swapping in proteins. Chapter in Comprehensive Biophysics, Ed. Daggett V, Elsevier, in press.
- Liu L, Koharudin LM, Gronenborn AM, and Bahar I. A comparative analysis of the equilibrium dynamics of a designed protein inferred from NMR, X-ray, and computations. Proteins. 2009, 77: 927-39.
- Iwatani Y, Chan DS, Liu L, Yoshii H, Shibata J, Yamamoto N, Levin JG, Gronenborn AM, and Sugiura W. HIV-1 Vif-mediated ubiquitination/degradation of APOBEC3G involves four critical lysine residues in its C-terminal domain.Proc Natl Acad Sci USA. 2009, 106: 19539-44.
