Thesis Title: Structure-Function Studies of the Metabotropic Glutamate Receptor Type 6 (mGluR6) and Comparison with Rhodopsin
Graduation Date: 2011
PhD Advisor: Dr Judith Klein-Seetharaman
Kalyan's research efforts were on investigating the structure-function relationships in metabotropic glutamate receptor type 6 (mGluR6) a G-protein coupled receptor selectively expressed in the retina using both computational and biophysical tools. His thesis works involved identifying novel orthosteric and allosteric ligands for mGluR6 and investigation of their effects on mGluR6 structure and function.
Current location: Sr. Research Scientist with Biological E. LTD, Hyderabad Area, India
Publications:
- Isin, B., Tirupula, KC, Oitvai, ZN, Klein-Seetharaman, J., and Bahar, I (2012) Identification of motions in membrane proteins by elastic network models and their experimental validation. Methods Mol Biol 914: 285-317
- Moitra S, Tirupula KC, Klein-Seetharaman J, Langmead CJ. (2012) A minimal ligand binding pocket within a network of correlated mutations identified by multiple sequence and structural analysis of G protein coupled receptors. BMC Biophys. 2012;5(1):13
- Dutta, A., Tirupula, KC, Alexiev, U., and Klein-Seetharaman, J. (2010) Characterization of membrane protein non-native states. 1. Extent of unfolding and aggregation of rhodopsin in the presence of chemical denaturants. Biochemistry 49: 6317-28
- Qi Y, Dhiman HK, Bhola N, Budyak I, Kar S, Man D, Dutta A, Tirupula K, Carr BI, Grandis J, Bar-Joseph Z, Klein-Seetharaman J. (2009) Systematic prediction of human membrane receptor interactions. Proteomics 9(23):5243-55
- Tirupula, K. C., Balem, F., Yanamala, N., and Klein-Seetharaman, J. (2009) pH-dependent interaction of rhodopsin with cyanidin-3-glucoside. 2. Functional aspects. Photochem Photobiol 85(2), 463-470
- Yanamala, N., Tirupula, K. C., Balem, F., and Klein-Seetharaman, J. (2009) pH-dependent interaction of rhodopsin with cyanidin-3-glucoside. 1. Structural aspects. Photochem Photobiol 85(2), 454-462
- Yanamala, N., Tirupula, K. C., and Klein-Seetharaman, J. (2008) Preferential binding of allosteric modulators to active and inactive conformational states of metabotropic glutamate receptors. BMC bioinformatics 9 Suppl 1, S16
- Gopi, H. N., Tirupula, K. C., Baxter, S., Ajith, S., and Chaiken, I. M. (2006) Click chemistry on azidoproline: high-affinity dual antagonist for HIV-1 envelope glycoprotein gp120. ChemMedChem 1(1), 54-57
