Research Interests:
Foldamers are unnatural oligomers with a propensity to adopt well-defined conformations. These molecules have seen success in the mimicry of canonical peptide secondary structures such as -helices and -sheets. Current efforts in the field involve the application of foldamer design strategies to mimic higher-order protein structures and novel peptide architectures. Disulfide-rich peptides are notable candidates for foldamer research due to their intricate folding patterns and potent bioactivities. I am interested in establishing foldamer design principles for the synthesis of disulfide-rich peptide analogs with heterogeneous backbone modifications that manifest specific conformations, desired functionality and improved pharmacological properties.
Education:
B.S. in Microbiology, University of Hawaii at Manoa, 2008
M.S. in Molecular Biosciences and Bioengineering, University of Hawaii at Manoa, 2014
PhD Advisor: Dr. Seth Horne
Lab Address:
Department of Chemistry
Chevron Science Center 1406
219 Parkman Avenue
email:
Publications:
- Werner HM, Cabalteja CC, Horne WS. (2015) Peptide Backbone Composition and Protease Susceptibility: Impact of Modification Type, Position, and Tandem Substitution. Chembiochem 2016, 17(8):712-8.
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Cabalteja, C. C.; Mihalko, D. S.; Horne, W. S., Heterogeneous-Backbone Foldamer Mimics of a Computationally Designed, Disulfide-Rich Miniprotein. ChemBioChem 2019, 20 (1), 103-110.
