Research Interests:

I study the structural basis of dimerization and maturation of HIV-1 reverse transcriptase (RT).  This viral enzyme is a primary target in the current treatments for HIV-1 infection.  The biologically active form of the enzyme requires dimerization of the RT subunits and proteolytic processing of one of these subunits.  Little structural data currently exists regarding the mechanisms of these dimerization and maturation processes which could provide attractive therapeutic targets for future antiretroviral therapies.  Our lab uses solution nuclear magnetic resonance (NMR) spectroscopy to determine structures of viral enzymes, and integrate our structural understanding into further mechanistic and functional studies.


B. Sc. in Biophysics, Centenary College of Louisiana, 2006

PhD Advisor: Dr. Rieko Ishima

Lab Address: 
Room 1037
Biomedical Science Tower 3
3501 Fifth Ave.
Pittsburgh, PA 15260

email: rls128{AT}