Jacob Spiegel

Research Interests:

While at the University of Pittsburgh I've had the opportunity to work on a number of projects across several fields.

From 2013 to 2017 I worked with Dr. Roger Hendrix researching fundamental phage biology. I worked on two projects while in his lab. I studied non-canonical ribosome translation in bacteriophage ΦHau3, in which the ribosome bypassed a 10 nucleotide region and continued translation downstream. My other project was crystallizing and studying the chaperone tail assembly proteins in bacteriophage λ.

Following the passing of Dr. Roger Hendrix, I join the lab or Dr. Jacob Durrant, working on computation biology with focuses in computer-aided drug design (CADD), Molecular Dynamics, and program development. My dissertation focuses on the development of the genetic algorithm for de novo computer-aided drug design, AutoGrow4, and its application to poly(ADP-ribose) polymerase 1 (PARP-1).

 

 

 

Education:

Biomedical Engineering BE, State University of New York at Stony Brook, 2013

PhD Advisor: Dr. Jacob Durrant

Lab Address:

A318 Langley Hall

 

 

email: jspiegel[at]pitt.edu

Publications:

  • Spiegel, J.O., Durrant, J.D. AutoGrow4: an open-source genetic algorithm for de novo drug design and lead optimization. J Cheminform 12, 25 (2020). https://doi.org/10.1186/s13321-020-00429-4

  • Ropp, P.J., Spiegel, J.O., Walker, J.L. et al. Gypsum-DL: an open-source program for preparing small-molecule libraries for structure-based virtual screening. J Cheminform 11, 34 (2019). https://doi.org/10.1186/s13321-019-0358-3