Manish Aryal

Research Interests:

I am interested in deciphering the structural basis of protein-protein interactions between HIV protein and host cell proteins. I will be using various structural methods to deepen our understanding of how HIV protein Nef activates Tec family kinases.

 

 

 

 

 

Education:

B.A. in Biochemistry and Molecular Biology, The College of Wooster (Wooster, OH), May 2014

PhD Advisor: Dr. Thomas Smithgall

Lab Address: 

University of Pittsburgh
Department of Microbiology and Molecular Genetics
533 Bridgeside Point II

450 Technology Dr.

Pittsburgh, PA 15219

 

email: manish.aryal - AT - pitt.edu

Publications:

  • Fraga D, Aryal M, Hall JE, Rae E, Snider M. Characterization of the arginine kinase isoforms in Caenorhabditis elegans. Comp Biochem Physiol B Biochem Mol Biol 2015; 187:85-101

  • Li, W. F., Aryal, M., Shu, S. T., and Smithgall, T. E. (2020) HIV-1 Nef dimers short-circuit immune receptor signaling by activating Tec-family kinases at the host cell membrane. J Biol Chem 295, 5163-5174

  • Fraga, D., Stock, K., Aryal, M., Demoll, C., Fannin, L., and Snider, M. J. (2019) Bacterial arginine kinases have a highly skewed distribution within the proteobacteria. Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology 233, 60-71

  • Fraga, D., Aryal, M., Hall, J. E., Rae, E., and Snider, M. (2015) Characterization of the arginine kinase isoforms in Caenorhabditis elegans. Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology 187, 85-101